State Route 595 (SR 595, OH 595) is a north–south state highway in southeastern Ohio, a U.S. state. The route's southern terminus is at a diamond interchange with the U.S. Route 33 expressway approximately 3.5 miles (5.6 km) southeast of Logan. Its northern terminus is at a T-intersection with State Route 216 in New Straitsville, just two blocks southeast of State Route 216's northern terminus at State Route 93.

This state highway travels through the counties of Hocking and Perry along its way. No part of State Route 595 is incorporated in the National Highway System, a network of highways deemed most important for the economy, mobility and defense of the nation.

State Route 595 was created in 1937 along the routing that it maintains to this day through eastern Hocking County and extreme southern Perry County. The highway has not experienced any major changes to alignment since it was established.