Virginia State Route 41 (SR 41) is a primary state highway in the U.S. state of Virginia. Known as Franklin Turnpike, the state highway runs 21.14 miles (34.02 km) from SR 293 in Danville north to SR 57 in Callands.

SR 41 begins at an acute intersection with SR 293 (Main Street) in the northern part of the city of Danville. The state highway heads northwest and intersects U.S. Route 29 Business (Piney Forest Road) before leaving the independent city and entering Pittsylvania County. SR 41 passes through the unincorporated communities of Mount Hermon and Pleasant Gap, where the highway crosses White Oak Mountain. The state highway curves west then veers north at Swansonville. SR 41 reaches its northern terminus at SR 57 (Callands Road) in Callands. The state highway follows the height of land north of the watershed of the Sandy River, which empties into the Dan River in Danville. To the north of SR 41 are the watersheds of Little Falls Creek east of White Oak Mountain and the Bannister River west of the mountain; these streams empty into the Dan River at Danville and near South Boston, respectively.