Highway 345 (AR 345, Ark. 345, and Hwy. 345) is a designation for two north–south state highways in Baxter County, Arkansas. A western segment of the route runs 3.36 miles (5.41 km) between US 62 BUS in Cotter and US 62/US 412 in Gassville. An eastern segment runs 0.63 miles (1.01 km) from US 62 to Hwy. 126 in Gassville.

Hwy. 345 begins at the intersection of US 62 BUS, Combs Avenue, and Cotter Road in Cotter. It first heads south on Cotter Road crossing a railroad at-grade. It runs northeast through the southern part of Cotter paralleling the White River before zig-zaging its way north when it enters Gassville and terminates at US 62/US 412.

The other segment of Hwy. 345 begins at the intersection of Lakeview Drive and US 62/US 412. It heads north for about 0.33 miles (0.53 km) on Lakeview Drive before turning east onto Vine Street and terminating at Hwy. 126.

The entire route is in Baxter County.

The entire route is in Gassville, Baxter County.