State Highway 273 or SH 273 is a state highway that runs from Pampa in northern Texas east and south to SH 203 near Hedley.

The route was originally designated in 1939 from Pampa to McLean as part of a general redescription of the state highway system. In 1990 the current route was completed by redesignating Farm to Market Road 2695 from McLean to SH 203 as part of SH 273.

Beginning at a junction with US 60 at Pampa in Gray County, SH 273 runs south to a junction with Loop 171. In Pampa the highway is known as Cuyler Street and Barnes Street. After a brief co-routing with Loop 171, the highway runs southeast to Lefors and then south to a junction with Interstate 40 at McLean, where the route is known as Sitter Street. SH 273 then runs almost directly south to its final junction with SH 203 near Hedley in Donley County. Most of the terrain covered by the highway is lightly populated ranch and oil country.