South Carolina Highway 310 (SC 310) is a state highway in the southeastern part of the U.S. state of South Carolina. The highway runs 8.4 miles (13.5 km) in a south-north orientation from Holly Hill north to Vance, and then northwest to its northern terminus, completely within Orangeburg County.

SC 311 begins at an intersection with US 176 in Holly Hill. The route heads north to an intersection with SC 45, north of the city. The road continues north into the city of Vance, where it intersects SC 210. After leaving Vance, SC 310 heads northwest and meets its northern terminus, at an intersection with SC 6, just northwest of the city.

The entire route is in Orangeburg County.