South Carolina Highway 200 (SC 200) is a primary state highway in the U.S. state of South Carolina. It connects the cities of Winnsboro, Great Falls, and Lancaster.

SC 200 is mostly a rural two-lane highway, traversing northwest from Winnsboro, through Great Falls and Lancaster, to the North Carolina state line.

Established in 1937 as a renumbering part of SC 93 to match NC 200; it originally traversed 7 miles (11 km) from US 521 to the North Carolina state line. By 1952, SC 200 was extended to its current southern terminus in Winnsboro; this replaced SC 93 from Lancaster to Great Falls and SC 22 from Great Falls to Winnsboro.