South Carolina Highway 145 (SC 145) is a primary state highway in the U.S. state of South Carolina. It serves to connect Chesterfield with central Chesterfield County and McBee.

SC 145 is a two-lane rural highway that traverses 26.0 miles (41.8 km), from US 1, near McBee, through the county seat of Chesterfield, to the North Carolina state line. It also passes through forest and wildlife refuge areas.

The first SC 145 appeared in 1941 or 1942 as a new primary route from SC 644 to US 15, north of Walterboro. In 1948, it was downgraded to secondary status, known today as McLeod Road.

The current SC 145 was established in 1960 as a renumbering of SC 85; little has changed since.

Established in 1937 as a renumbering of SC 95, it ran from US 1, near McBee, through Chesterfield, to the North Carolina state line. It was renumbered to SC 145 to match with NC 145.

The entire route is in Chesterfield County.