Minnesota State Highway 28 is a highway in west-central and central Minnesota, which runs from South Dakota Highway 10 at the South Dakota state line near Browns Valley and continues east to its eastern terminus at its intersection with the former route of U.S. Highway 10 in Little Falls.

Highway 28 is 142 miles (229 km) in length.

State Highway 28 serves as an east–west route between Browns Valley, Morris, Glenwood, Sauk Centre, and Little Falls.

The western terminus for Highway 28 is at the Minnesota - South Dakota state line in Browns Valley, at the Little Minnesota River, where Highway 28 becomes South Dakota Highway 10 upon crossing the state line.

Highway 28 parallels State Highway 27 throughout its route.

The Sam Brown Monument State Wayside Park is located on Highway 28 in Traverse County at Browns Valley.

The highway overlaps Highway 27 for the last 14 miles of its route, until its terminus in Little Falls at the former alignment of U.S. Highway 10, which is now a city street.

Highway 28 is legally defined as Constitutional Route 28 in the Minnesota Statutes.

State Highway 28 was authorized in 1920.

The route was completely paved by 1940.