State Route 800 is a north–south state highway in the eastern portion of the U.S. state of Ohio. Its southern terminus is at State Route 7 near New Matamoras, and its northern terminus is at its interchange with Interstate 77 in Canton.

Prior to 1969, State Route 800 was part of State Route 8. At that time, SR 8 between Akron and Canton was eliminated. The portion south of Canton was renumbered to SR 800.