Kentucky Route 880 is a 3-mile-long east–west state highway that forms a connector between U.S. Route 231 and KY 234 in the city of Bowling Green, Kentucky. The western terminus of the route is at U.S.231 in Bowling Green. The eastern terminus is at Kentucky Route 234 near the community of Indian Hills east of downtown.

The old route started at the junction of KY 185 (Sixth Avenue) and Gordon Avenue near downtown Bowling Green. KY 185 turned north onto Gordon Avenue while Sixth Avenue became Veterans Memorial Boulevard and KY 880. From its starting point, KY 880 ran approximately 3.6 miles (5.8 km) around northwestern Bowling Green, intersecting Kentucky Route 2665 (Glen Lily Road) ahead of a junction with U.S. Route 231. US 231 turned south onto the loop, joining KY 880, while U.S. Route 231 Business, the former routing of US 231 into downtown Bowling Green, continued east.

The conjoined routes, collectively named Campbell Lane, ran for five miles (8 km) around the southern portion of Bowling Green, passing through one of the main commercial districts of the city. 1.5 miles (2.4 km) into the concurrency, US 231 and KY 880 intersect the conjoined U.S. Route 68/Kentucky Route 80. Two intersections to the east, Campbell Lane meets U.S. Route 31W. The routes remained overlapped to another intersection with US 231 Business, where US 231 separated from the loop and followed its previous alignment south out of the city. The old route also contained the current route from this point eastward.

Starting at a junction with US 231 and US 231 business, KY 880 runs to the northeast for approximately three miles as Lovers Lane until reaching its eastern terminus at KY 234, less than a mile from Interstate 65 exit 26.

KY 880 is currently partially two lanes before bridging out into four lanes near its Eastern Terminus.Lovers Lane is currently undergoing widening to accommodate increased residential and commercial buildup along the remaining two lane section.

KY 880 was added to the State Secondary and Rural Secondary systems on 9 February 1983. On 6 April 1990, the Northwest Bypass, a 4.389-mile (7.063 km) segment of KY 880 between KY 185 and Tomblinson Way, was added to the State Secondary System. An additional 0.638 miles (1.027 km) were added to KY 880 on 18 May 1992.

On 9 August 1999, US 231 was rerouted onto KY 880 between its two junctions with KY 880 west and south of the city, forming a concurrency between the two routes. The former alignment of US 231 through Bowling Green was re-designated as US 231 Business.

In March 2008, a good deal of the former length of KY 880 was redesignated as new routing for, from west to east, US 68, KY 80, and US 231. The portion of the highway that was formerly conjoined with US 231 is now designated solely as that highway.

The entire route is in Bowling Green, Warren County.