State Route 59 (SR 59) is a state highway that runs southwest-to-northeast through portions of Jackson, Banks, Franklin, and Hart counties in northeastern Georgia. The route runs from its southwestern terminus at US 441 and SR 15 in Commerce to its northeastern terminus east of SR 77 at the northwestern shore of Lake Hartwell.

The route initially runs northeast from its southwestern terminus in Commerce in Jackson County, and very closely parallels I-85 for its entire distance. SR 59 then crosses through the southeastern portion of Banks County and continues northeast in the direction of Carnesville in Franklin County. The route then runs through Lavonia before reaching its northeastern terminus in Hart County.

Before the construction of Lake Hartwell, SR 59 continued into South Carolina as South Carolina Highway 59. With the I-85 bridge less than a mile away from the old crossing, the states had no need to directly reconnect the roads. SR 59 is NOT cosigned with I-85 on either side of the lake and the two highways do not officially connect.