State Route 39 (SR 39) is a state highway that runs south-to-north through portions of Seminole, Miller, Early, Clay, Quitman, and Stewart counties in southwestern Georgia. The route runs from its southern terminus at Lake Seminole in southern Seminole County to its northern terminus at US 27 and SR 1 north of Lumpkin.

From its southern terminus at Lake Seminole, R 39 travels north to Donalsonville, where it is briefly concurrent with SR 91. After intersecting US 84/SR 38, the routes continue to the north side of the city, where SR 39 departs and continues north into Miller County. After briefly traveling north in Miller County, the route jogs to the west into Early County, where it resumes its northward route to Blakely. In Blakely, SR 39 becomes concurrent with U.S. Route 27 Business / State Route 1 Business (US 27 BUS/SR 1 BUS) north through downtown. On the north side of the city, SR 39 departs US 27 BUS/SR 1 BUS, and, after briefly traveling west concurrent with SR 62 Bypass (SR 62 BYP), continues north to Fort Gaines, where it is briefly concurrent with SR 37. North of Fort Gaines, SR 39 runs along the eastern shore of Walter F. George Lake, and passes through George T. Bagby State Park. Southeast of Georgetown, the route becomes concurrent with US 82/SR 50 westward. Just to the east of Georgetown, SR 39 departs to the north, running parallel to the Chattahoochee River. Shortly after passing Florence Marina State Park, the route takes a drastic turn to the east at Omaha where it meets SR 39 Spur, and continues east to its northern terminus at US 27/SR 1 north of Lumpkin.

SR 39 is a rural route, and as a result, sees very little traffic. Most of the route sees an Average Annual Daily Traffic (AADT) of less than 2,000 vehicles.

The portion of SR 39 north of Georgetown was formerly SR 375. However, it was renumbered as an extension of SR 39 after just a few months.

State Route 39 Connector (SR 39 CONN) is a 15.84 mile route connecting the SR 39 mainline near Florence Marina State Park with US 27/SR 1 in Lumpkin. The route passes through Providence Canyon State Park.

State Route 39 Spur (SR 39 Spur) is a short spur that runs from the SR 39 mainline in Omaha westward. After crossing the Chattahoochee River into Alabama, the route becomes Alabama State Route 208.