US 221 (SC) Intersections with interstate highways 2025-10-28 Roadnow US 221 (SC) Intersections with interstate highways MAP I-85, near Spartanburg, Tennessee map • nearbyMAP I-26, near Roebuck, Tennessee map • nearbyMAP I-385SC, near Laurens, Tennessee map • nearbyMAP I-26, near Roebuck, Tennessee map • nearbyMAP I-585SC, near Spartanburg, Tennessee map • nearbyMAP I-585SC map • nearbyMAP I-585SC, near Spartanburg, Tennessee map • nearby
