State Route 626 (SR 626, OH 626) is a north–south state highway in the northeastern portion of the U.S. state of Ohio. The southern terminus of State Route 626 is at State Route 165 approximately 1.5 miles (2.4 km) southeast of the hamlet of North Lima. Its northern terminus is at a signalized intersection with State Route 7 nearly 2 miles (3.2 km) south of the unincorporated community of Boardman.

Established in the late 1930s, State Route 626 is a two-lane highway that primarily serves local traffic in the southeastern Mahoning County municipality of Beaver Township. Along its path, State Route 626 duplexes briefly with State Route 164 to cross over the Ohio Turnpike (Interstate 76) just west of the partial interchange it has with Interstate 680.

This state highway runs exclusively within Beaver Township in southeastern Mahoning County. State Route 626 is not included within the National Highway System.

State Route 626 begins at the intersection of State Route 165 and County Road 26 (E. South Range Road) approximately 1.5 miles (2.4 km) southeast of North Lima. Running northwesterly from that intersection, the two-lane state route passes a number of houses, with woods abutting the roadway along the way. At Miley Road, the highway turns to the north-northwest, and passes just to the west of the partial Interstate 680 interchange off of the Ohio Turnpike (Interstate 76). State Route 626 then bends to the northwest, and comes into a T-intersection with State Route 164. Here, State Route 626 turns to the northeast, and runs concurrently with State Route 164 for less than 0.1 miles (0.16 km) to cross the Ohio Turnpike, then resumes its solo trek to the northwest. The route passes by a couple of commercial buildings as it departs the intersection, then travels amidst a blend of wooded terrain and open fields with scattered homes along the way. State Route 626 intersects County Road 30 (E. Calla Road), then continues in a northwesterly fashion, crossing railroad tracks and then passing by the Kreps Road intersection. Next, the highway passes into a more heavily residential setting, and intersects a number of side streets. Finally, State Route 626 passes a couple of commercial businesses as it enters from the southeast into a five-approach signalized intersection approximately 2 miles (3.2 km) south of Boardman that marks its endpoint, where it meets State Route 7, which traverses the intersection north-to-south, and County Road 32 (Western Reserve Road), which passes through it east-to-west.

State Route 626 was created in 1937 along the routing that it currently occupies between State Route 165 and State Route 7. The highway has not experienced any major changes since its inception.

The entire route is in Beaver Township, Mahoning County.