South Carolina Highway 41 (SC 41) is a 122-mile (196 km) state highway, connecting the Charleston region with eastern portions of the Pee Dee region in South Carolina. It serves as an alternative route to U.S. Highway 52.

The route travels generally in a south-north direction, beginning in Mount Pleasant and ending at the North Carolina state line just north of Lake View, where it continues as North Carolina Highway 41 towards Lumberton. The route is mostly rural, though it serves as an important arterial in suburban Mount Pleasant and passes through several small towns on its route northwards. It also provides several key river and swamp crossings in the Pee Dee region.

Established in 1951 or 1952 as a new alternate route of SC 41 through Marion, though it did replace part of SC 175 south of Marion.

Established between 1993-1996, it replaced mainline SC 41 through downtown Andrews. This is second business loop through Andrew, following exactly the same route from 1960-63 until 1970.