South Carolina Highway 2 (SC 2) is a state highway in the U.S. state of South Carolina that runs 3.9 miles (6.3 km) between two portions of the US 21/US 176/US 321 concurrency in Lexington County, South Carolina. The southern 2.4 miles (3.9 km) of the highway is known as Frink Street while the northern 1.5 miles (2.4 km) of the highway is known as State Street.

SC 2 is one of the original state highways. The original route went from the Georgia state line north of Mountain Rest heading east towards Greenville before turning southeast and ending in Charleston, spanning over 250 miles (400 km). The road began construction in 1923 and ended 11 years later in 1932. The road has been reduced to just under 4 miles.

SC 2 is a 3.9 mile (6.3 km) two-lane road just southwest of Columbia, serving as a "business route" for Cayce. It begins at the US 21/US 176/US 321 concurrency heading northeast. It then takes a turn to the north and runs parallel to the Congaree River to its west. Shortly after passing US 1, the highway ends at US 378 in West Columbia. The highway runs by an elementary school, Brookland-Cayce High School, two shopping centers, and a park.

The entire highway is in Lexington County.