North Carolina Highway 59 is a North Carolina highway that runs through Cumberland County from Interstate 95 near Hope Mills to US 401 BUS in Owens, just west of Fayetteville.

North Carolina Highway 59 is an urban route southwest of Fayetteville. NC 59 begins at Interstate 95 (Exit 41) and proceeds north from there intersecting U.S. Route 301 shortly thereafter at a partial cloverleaf interchange. NC 59 continues north entering the Town of Hope Mills. North Carolina Highway 162 is intersected just north of Hope Mills, as NC 59 continues north through the suburban parts of Fayetteville. NC 59 comes to its northern end at US 401 BUS (Raeford Road).

North Carolina Highway 59 was first commissioned in 1932 as a new primary highway from US 1/NC 50 in Raleigh following present day US 401 to Louisburg and ending at US 158/NC 48 in Warrenton. In 1957, NC 59 was renumbered in its entirety by US 401.

Today's alignment was commissioned in 1958 and initially it ran from US 401 west of Owens and around the north side of Fayetteville and ended at US 401 north of Fayetteville. In 1963, NC 59 was extended south through Hope Mills and ended at US 301 as an upgrade to State Routes 1141, 1118, and 1124. By 1968, the northern terminus of Highway 59 was truncated to its current endpoint at US 401 BUS in Owens. US 401 BUS replaced the original alignment of NC 59 north of there. In 1982, when I-95 was opened around Fayetteville, NC 59 was extended to it.

The entire route is in Cumberland County.