Pennsylvania Route 201 (designated by the Pennsylvania Department of Transportation as State Route 201) is a 25-mile (40 km) long south-north state highway located in southeast Pennsylvania in the counties of Fayette and Westmoreland. The southern terminus is at U.S. Route 119/PA 711 in Connellsville. The highway heads northwest and meets up with Pennsylvania Route 51 twice at two separate locations and Interstate 70 in Rostraver Township. The northern terminus is at Pennsylvania Route 136 in Rostraver Township.

PA 201 begins at an intersection with US 119 and PA 711 in western Connellsville. Named Vanderbilt Road, PA 201 quickly exits the city and heads northwest toward the borough of Vanderbilt. Immediately after entering Vanderbilt, PA 201 intersects the southern terminus of PA 819 and continues to the south and west through the borough, becoming Flatwoods Road to the west. In Perry Township, just south of Star Junction, PA 201 intersects PA 51 at a cloverleaf interchange. West of this point, PA 201 takes a more northerly route toward Fayette City.

In Fayette City, PA 201 runs north as the one-way pair of Main and 2nd Streets, then heads north toward Lynnwood and Pricedale. In Pricedale, PA 201 becomes Rostraver Road and serves a shopping center before intersecting I-70 at exit 43. Now in Westmoreland County, PA 201 turns northeast toward West Newton. The route passes a the Mon Valley Education Center of Westmoreland County Community College and Belle Vernon Area High School before intersecting PA 51 again at a partial interchange. The route continues for another couple miles before ending at an intersection with PA 136 less than a quarter of a mile west of West Newton.

In 1928, Pennsylvania Route 71 was signed as the section from Interstate 70 South at the Donora/Monessen Interchange to the current northern terminus at Pennsylvania Route 136 in West Newton. Also at that time, the stretch of road south of Interstate 70 was known as Pennsylvania Route 711. Then in 1964, the entire route got the numbering of Pennsylvania Route 201.