State Route 41 (SR 41, Ohio 41) is a north–south state highway in the southern and western portions of the U.S. state of Ohio. Its southern terminus is at the Ohio River on the Simon Kenton Memorial Bridge in Aberdeen (Business U.S. Route 62 continues south through Maysville, Kentucky from this point); and its northern terminus is along State Route 48 at U.S. Route 36 in Covington. Throughout its southern portion the route is quite hilly as it passes predominantly northward through scenic areas with state parks and monuements. Along its northern portion the route heads in a more westerly direction across mainly flat terrain as a major road through the cities of Washington Court House, Springfield, and Troy, all of which are experiencing growth in industry and commerce.

On November 9, 2012, the Clark County-Springfield Transportation Coordinating Committee announced that a roundabout will be constructed at the intersection of SR 41 and SR 235 in Pike Township, which has been the site of numerous vehicle crashes, including five fatalities from 1992 to 2013. Construction is expected to begin in summer 2014 and is estimated to cost $1.3 million to $1.5 million. It will be the first roundabout in Clark County and is believed it will be the first in Ohio with all approaches at high speed, 55 mph (89 km/h).