K-16 is a state highway in Kansas. It starts at a junction with US 77 just north of Randolph and ends in Tonganoxie with US 24 and US 40.

K-16 begins north of Randolph on US 77 and crosses Tuttle Creek Lake. Near the town of Blaine, K-16 crosses The Oregon Trail. K-16 continues through Holton until turning south. K-116 continues to head eastward through Larkinburg and Arrington until ending at Cummings in Atchison County.

K-16 continues through Valley Falls, crossing the Delaware River until meeting with US 59. K-16 then runs concurrent with US 59 through Oskaloosa until heading east again through McLouth and winding through Leavenworth County until coming to an end at an intersection with US 24 and US 40 in Tonganoxie.

Between 1926 and 1936, K-16 was located in Atchison County and Doniphan County, starting at US 73 in Atchison and ending at US 36 in Troy.

A southern terminus was located in Montgomery County and Neosho County starting in Chanute and ending at the Oklahoma state line in Coffeyville.