State Route 160 is a north–south state highway in the southeastern portion of the U.S. state of Ohio. Its southern terminus is at State Route 7 in Gallipolis, and the route heads north. It meets U.S. Route 35 at an interchange with various collector and distributor ramps. From there, the route passes through Vinton in northern Gallia County. Following an intersection with State Route 32, the route heads in a more westerly direction until it meets and its northern terminus is at State Route 93 in Hamden.