North Carolina Highway 141 (NC 141) is a North Carolina state highway connecting Marble to a community just outside Murphy known as Peachtree.

The entire 8.1-mile (13.0 km) length of NC 141 is contained within Cherokee County, NC. The northern terminus is at US 19/US 129/US 74, at Marble Road in Marble; the southern terminus is at US 64 Alternate in Murphy.

The route serves as an important transportation link across Cherokee County, providing access for traffic from Marble and Andrews to the Peachtree community, where Murphy Medical Center, the area's only major hospital, and Tri-County Community College are located. Conversely, the reverse route provides quick access from these areas, as well as Hayesville, to the Andrews-Murphy Airport (KRHP).

The route passes through several small communities along the way from Marble to Peachtree, including Vengeance Creek and Rowland Hill.

The entire route is in Cherokee County.