Kentucky Route 393 (KY 393) is a state highway in Oldham County, Kentucky, United States. Its northern terminus is US 42. From there it continues 5.5 miles (8.9 km) south to a 0.04-mile (0.064 km) overlap with KY 146 in Buckner. It then splits south to continue for 2.5 miles (4.0 km) where it junctions KY 22 near Centerfield. It follows KY 22 east for 1-mile (1.6 km) until it splits to the south. It continues 1.5 miles (2.4 km) south and then terminates at Mount Zion Road. There are no low clearances or weight limits on this particular state route. As of 2009, this route has been relocated and improved. From the interchange of Interstate 71, it has been widened to three lanes with a center turn lane. It has been improved to the junction of State Route 22.

It serves the following:

Oldham County Middle and High Schools and a connector route from Goshen to Buckner.