State Route 380 (SR 380) is a short highway that runs west-to-east entirely in Jasper County in central Georgia. The route acts as a partial bypass of Monticello.

SR 380 starts at an intersection with SR 83 southwest of Monticello. The route swings around to the southwest to an intersection of SR 11 south of Monticello. Then, SR 380 goes to the northeast to an intersection with SR 212 southeast of Monticello. Just past this intersection, SR 380 meets its eastern terminus at SR 16 east of Monticello.

The entire route is in Monticello, Jasper County.