Major Cities along US 21 (SC) 2025-10-25 Roadnow US 21 (SC) Major Cities MAP Saint Helena Island MAP Beaufort MAP Ladys Island MAP Seabrook MAP Sheldon MAP Lobeco MAP Yemassee MAP Early Branch MAP Walterboro MAP Islandton MAP Ruffin MAP Williams MAP Smoaks MAP Branchville MAP Rowesville MAP Orangeburg MAP Saint Matthews MAP Swansea MAP Gaston MAP West Columbia MAP Cayce MAP Columbia MAP Blythewood MAP Ridgeway MAP Winnsboro MAP Great Falls MAP Fort Lawn MAP Edgemoor MAP Catawba MAP Rock Hill MAP Fort Mill MAP Pineville MAP Charlotte MAP Port Royal
