South Carolina Highway 57 (SC 57) is a state highway in the northeastern part of the U.S. state of South Carolina. The highway runs 25.9 miles (41.7 km) in a southeast-northwest orientation from the unincorporated community of Fork northwest through Dillon to Little Rock and then curves northeasterly to the North Carolina state line, north of Little Rock.

SC 57 begins at an intersection with SC 41 and SC 41 Alternate in Fork. The route heads northeast through the town of Floydale until it enters Dillon.

In Dillon, the highway intersects SC 9, and the two routes form a concurrency to the northwest. They run along East Main Street until they meet US 301/US 501 and SC 34. SC 9/SC 57 turn right onto US 301/US 501 (North 2nd Avenue) slightly to the northeast. At Julia Lane, SC 9/SC 57 depart the concurrency to the northwest. They meet an interchange with I-95 just before leaving the city.

At the northern part of Little Rock, SC 57 departs the concurrency curving to the northeast until it meets its northern terminus, the North Carolina state line north of Little Rock. Here, the roadway continues as Fairley Road northeast to Raemon.

The entire route is in Dillon County.