Pennsylvania Route 107 (PA 107) is a 17-mile (27 km) long state highway located in Wyoming and Lackawanna counties in Pennsylvania. The western terminus is at US 6/US 11 in Factoryville. The eastern terminus is at US 6 in Jermyn. The length of this route serves as a short-cut for thru-traffic on US-6 creating a bypass of Scranton and Clarks Summit.

PA 107 begins at at intersection with US 6/US 11 on the border of Factoryville and Clinton Township in Wyoming County, heading north into Clinton Township on a two-lane undivided road. The route heads through forested areas, curving north-northeast and passing under a Canadian Pacific railroad line. The road crosses into Nicholson Township and heads northeast through more wooded areas with some homes, turning east and passing to the south of Lake Sheridan.

PA 107 enters Benton Township in Lackawanna County and continues south of the lake before running through more woodland with some fields and homes, coming to an intersection with PA 407 in Fleetville. The road heads through more rural areas, coming to an interchange with I-81 before crossing into Scott Township. The route runs through more woods with farmland and residences, becoming Heart Lake Road and forming the border between Greenfield Township to the north and Scott Township to the south. PA 107 passes through Tompkinsville prior to turning southeast to fully enter Scott Township and pass through agricultural areas as it reaches an intersection with PA 247. The road heads through more farmland and woodland with some homes, crossing into Carbondale Township. Here, the route crosses a forested mountain. PA 107 heads into Mayfield and comes to an interchange with US 6 Business. Past this interchange, the road turns east and becomes Rushbrook Street and enters residential areas, briefly forming the border between Mayfield to the north and Jermyn to the south before fully entering Jermyn. The route passes over the Lackawanna River and a Delaware–Lackawanna Railroad line, heading into wooded areas and crossing back into Mayfield. PA 107 comes to its eastern terminus at an interchange with the US 6 freeway on the border of Mayfield and Archbald.