Wyoming Highway 72 is a 15.45 miles (24.86 km) state highway in eastern-central Carbon County that travels from Elk Mountain northwest to Hanna.

Highway 72 begins its south end at Carbon County Route 402 (East Main Street) in Elk Mountain. WYO 72 heads northwest out of Elk Mountain as Bridge Street and then loses the name when it leaves the town. At approximately 4 miles, WYO 72 intersects I-80 (Exit 255). Highway 72 continues heading northwest towards Hanna, Wyoming hence the road's name Hanna Road. At 14.3 miles, WYO 72 intersects US 30/US 287. WYO 72 then continues north from this intersection another mile or so and ends in Hanna named Adams Street.

Wyoming Highway 72 uses two inventory control numbers. ML 412 is used for the section from Hanna to US-30 while ML 404 is used for the section from US-30 to Elk Mountain. This results in an unusual situation where mileposts overlap. ML 412 starts at milepost zero at US-30 and continues through Hanna to milepost 3.02, while ML 404 starts at milepost 1.55 from US-30 and continues to milepost 15.98 in Elk Mountain. This means that there are two mileposts for every interval between 1.55 and 3.02.

The entire route is in Carbon County.