Wyoming Highway 112 is a 29.50-mile (47.5 km) state highway in north-central Crook County, Wyoming that runs from Hulett to the Montana-Wyoming State Line.

Wyoming Highway 112 begins its south end at Wyoming Highway 24 in Hulett. From there WYO 112 travels north to Montana-Wyoming State Line. The highway continues north from there a short distance as Montana Secondary Highway 326 to meet US 212 in Alzada, Montana.

The entire route is in Crook County.