West Virginia Route 598 is a v-shaped state highway located in the Bluefield, West Virginia area. The southern terminus of the route is at the Virginia state line south of the city, where WV 598 continues southward as State Route 598. The northern terminus of the route is at and U.S. Route 52 in Bluefield.

From its southern terminus at SR 598, WV 598 runs to the south-southwest for roughly two miles before intersecting U.S. Route 460. The two routes form a concurrency to the west for a quarter of a mile, where WV 598 turns north onto Cherry Drive. A short distance to the north, as Washington Street, WV 598 reaches the intersection of Washington Street and Cumberland Road. WV 598 turns east onto Cumberland Road for a quarter of a mile to an intersection with US 52.

The entire route is in Mercer County.