U.S. Route 24 is a major east–west route in the U.S. state of Colorado.

It traverses the Rocky Mountains, starting near Minturn. It then continues east for about 30 miles Leadville where it turns south and goes to Buena Vista where it becomes concurrent with US 285. It continues with Highway 285 to the small community of Antero Junction. After that, it spends its time as a mountainous two-lane highway through the town of Divide, where it meets SH 67. These highways overlap to Woodland Park. From there it passes through Crystola, Green Mountain Falls, Cascade as a 4-lane highway. Through Manitou Springs and Colorado Springs, where the road is known as Midland Expressway. Just east of Interstate 25, it is known as the Martin Luther King Jr Bypass. From Colorado Springs it continues northeast through several towns such as Falcon, Peyton, the city of Calhan, Ramah, Simla, and Matheson. When US 24 reaches Limon, it junctions with I-70/US 40/US 287/SH 71. It continues east (parallel to I-70) to Burlington where it joins I-70 to the Kansas state line.