State Highway 191 or SH 191 is a Texas state highway running from the north side of Odessa east to the western edge of Midland. This route was designated in 1978.

SH 191 was originally designated by 1933 on a route from Albany south to Coleman. By 1939, this route had been transferred to US 183.

The segment along 42nd Street in Odessa within Loop 338 was formerly designated Spur 492. This mileage was transferred to SH 191 in 1983.