State Route 133 (SR-133) is a state route in northeastern Tennessee in Johnson County. It begins at Shady Valley, Tennessee and runs northward for about 11 miles (18 km) to the Tennessee–Virginia state border.

SR-133 begins in Shady Valley, where it intersects with U.S. Route 421 (US 421), SR-34, and SR-91. The road progresses northward from Shady Valley through the communities of Crandull and Sutherland, passing through the Cherokee National Forest, to its terminus at the state border with Virginia.