State Route 1 (SR-1), known as the Memphis to Bristol Highway, is a mostly-unsigned state highway in the U.S. state of Tennessee that is 538 miles (866 km) long. It stretches all the way from Memphis in the southwest corner of the state to Bristol in the northeast corner. Most of the route is overlaid on U.S. Highway 70 and U.S. Highway 11W.

SR-1 begins at Interstate 55 on the Tennessee end of the Memphis-Arkansas Bridge. U.S. Highway 61, U.S. Highway 64, U.S. Highway 70 and U.S. Highway 79 come off the bridge alongside SR-1; US-61 soon turns south with State Route 14. The other three U.S. Highways split east onto State Route 3, and U.S. Highway 51 joins, only to split with State Route 4 where SR-1 turns east alone onto North Parkway. However, US-64, US-70 and US-79 soon rejoin SR-1 at State Route 57. All of SR-1 through Memphis, except for the section on its own, is a primary route.

After leaving Memphis, SR-1 runs along the following routes:

It is primary or secondary as follows:

In Bristol, SR-1 leaves U.S. Highway 11W right at the state line, and heads east on its own (as a primary route) along State Street. It turns south at U.S. Highway 11E/U.S. Highway 19, ending two blocks later at Broad Street (State Route 34).

State Route 1 traverses the counties shown in the table below.