South Carolina Highway 55 (SC 55) is a primary state highway in the U.S. state of South Carolina. It connects the city of Clover to Blacksburg, Rock Hill, and Charlotte, North Carolina.

SC 55 is a rural two-lane highway, with a median in and around Clover. It traverses 20.8 miles (33.5 km) from SC 5, near Kings Creek, to SC 49/SC 274, near Lake Wylie. Travelers to and from Charlotte, North Carolina would connect through SC 557, just east of Clover.

The first SC 55 appeared in either 1925 or 1926 as a new primary routing from SC 21, near Greenwood, to SC 24, in Friendship. By 1930, it was renumbered as part of SC 24 (today it is part of US 178).

The current SC 55 was established in 1931 as a new primary routing from Kings Creek to Lake Wylie. The highway was fully paved by 1942. In 2012, SC 55 was widen with a median through Clover.