South Carolina Highway 122 (SC 122), also known as Dave Lyle Boulevard, is a state highway in Rock Hill, York County, South Carolina. It runs about 5.2 miles (8.4 km) from the intersection with West Main Street in Rock Hill and continues west to Waterford Park Drive, also in Rock Hill. It will be extended soon to U.S. Route 521 (Charlotte Highway).

SC 122 starts an intersection between West Main Street and Dave Lyle Boulevard in downtown Rock Hill. From there, it follows Dave Lyle Boulevard northeasterly to an interchange with US Route 21 (US 21). The highway continues on a more easterly course to an interchange with Interstate 77 (I-77) before terminating at Waterford Park Drive.

The first SC 122 appeared in 1941 or 1942 as a new primary 1-mile (1.6 km) routing from SC 2, in Cayce, to US 1/US 21/SC 2/SC 5, in West Columbia. It was decommissioned in 1948.

The current SC 122 was established as a new primary routing in 1974 or 1975, it went from SC 72 Business east to Interstate 77. In 2001, it was extended to its current eastern terminus at Waterford Park Drive.

The entire route is in Rock Hill, York County.