State Route 286 (SR 286, OH 286) is a 9.97-mile (16.05 km) long east–west state highway in the southwestern portion of the U.S. state of Ohio. The western terminus of SR 286 is at U.S. Route 50 (US 50) nearly 5 miles (8.0 km) southwest of the village of Fayetteville. Its eastern terminus is at SR 134 approximately 7.25 miles (11.67 km) northwest of Sardinia.

The SR 286 designation was applied in 1931. The highway originally ran from its present junction with US 68 (at the time the duplex of SR 10 and SR 53) to its eastern terminus at SR 134.

In 1938, SR 286 was extended west-northwest along a previously un-numbered roadway to its present western terminus at US 50 southwest of Fayetteville.