State Route 208 (SR 208, OH 208) is an east–west state highway in central Ohio, a U.S. state. The western terminus of State Route 208 is at State Route 60 in Dresden, while its eastern terminus is at State Route 93 in Adamsville.

State Route 208, which runs east–west through the northern portion of Muskingum County, has no portion that is included as a part of the National Highway System.

Designated during the early years of the Ohio State Highway system, specifically in 1924, State Route 208 maintains the same Dresden-to-Adamsville routing today that it did when it first debuted. No significant changes have taken place to the highway itself since its inception, only the designation of the highways at its endpoints. What is now State Route 60 at State Route 208's western terminus was known as State Route 77 in 1924, and what is now State Route 93 at the eastern terminus of State Route 208 was originally designated as State Route 75.

The entire route is in Muskingum County.