North Carolina Highway 522 is a primary state highway in the state of North Carolina. The highway runs north–south from the South Carolina state line, near Sapps Crossroads, to North Carolina Highway 200, in Roughedge.

NC 522 is a short 5.84-mile (9.40 km) two-lane rural highway in Union County, passing through an area of mixed forest and farmland. Because it does not connect to any nearby town or city, it has little to no traffic.

Established as a new primary routing around 1951, it is complementary extension of South Carolina Highway 522; unchanged since.

The entire route is in Union County.