Maryland Route 564 (MD 564) is a state highway in the U.S. state of Maryland. Known for most of its length as Lanham Severn Road, the state highway runs 6.73 mi (10.83 km) from MD 450 in Lanham east to a dead end near a connection to MD 197 in Bowie.

MD 564 begins at a partial interchange with MD 450 (Annapolis Road) in Lanham. There is no access from westbound MD 450 to eastbound MD 564 or from westbound MD 564 to eastbound MD 450. Eastbound MD 564 exits from eastbound MD 450, passes under MD 450, and meets westbound MD 564 at an intersection where heading straight leads to Cipriano Road. The two directions of MD 564 come together as Lanham Severn Road, a two-lane road heading northeast paralleling the Amtrak Northeast Corridor and MARC's Penn Line at a distance. The state highway crosses Baldhill Branch and passes through the unincorporated community of Seabrook, where the road intersects Seabrook Road and passes the Seabrook MARC station. After passing through a commercial area in Seabrook, MD 564 passes several industrial properties on the railroad side of the highway. The state highway enters Glenn Dale, where the highway temporarily expands to a four-lane divided highway for intersections with Glenn Dale Road (unsigned MD 953A) and MD 193 (Glenn Dale Boulevard).

MD 564 continues northeast, passing Hillmeade Road and Springfield Road before entering the city of Bowie, where the highway's name changes to 9th Street. At Chestnut Avenue, which is unsigned MD 564A, the state highway assumes that street's name and turns south to cross the Amtrak Northeast Corridor just north of its junction with CSX's Popes Creek Subdivision. MD 564 turns east onto 11st Street, which heads west toward the railroad wye as unsigned MD 564C. After passing Race Track Road, which heads east toward an intersection with MD 197 (Laurel–Bowie Road), MD 564 curves south and reaches its southern terminus at the entrance to a farm adjacent to the Washington, Baltimore and Annapolis Trail's crossing of MD 197.

The entire route is in Prince George's County.

MD 564 has three unsigned auxiliary routes in Bowie.