State Route 72 (SR 72) is a state highway that runs west-to-east through portions of Clarke, Madison, and Elbert counties in northeastern Georgia. The route runs from its western terminus at US 29 and SR 8 just northeast of Athens to its eastern terminus at the South Carolina state line southeast of Elberton.

The route initially runs northeast and then east from its southern terminus in Clarke County into Madison County and the communities of Colbert, Comer, and Carlton, before turning northeast again and heading through Elberton in Elbert County. Once through Elberton, SR 72 heads southeast, and crosses into South Carolina over Richard B. Russell Lake.