State Route 64 (SR 64) is a state highway that runs southwest-to-northeast through portions of Berrien, Lanier, Atkinson, and Coffee counties in southern Georgia. The route runs from its southwestern terminus at US 129, SR 11, and SR 37 in Ray City to its northeastern terminus at SR 158 in rural Coffee County.

From its southern terminus in Ray City, State Route 64 travels through rural Berrien and Lanier counties before its intersection with SR 135. SR 64 then forms a concurrency with SR 135 as the route goes back into Berrien County. The overlap with SR 135 ends at the intersection of SR 168. SR 64 then overlaps with SR 168 and the route goes back into Lanier County. SR 64 then departs from its concurrency with SR 168 and goes through rural Lanier and Atkinson counties until its intersection with US 221. SR 64 forms a concurrency at its intersection with US 221 and the route treks north toward Pearson. US 441 joins the concurrency just south of Pearson. Once in Pearson, SR 64 leaves its concurrency with US 221 and US 441 at the intersection of US 82, where the route forms a very brief concurrency before turning north toward Coffee County. The route travels through rural Atkinson County before turning east along the Atkinson-Coffee County line. After a few miles, SR 64 turns north into Coffee County and travels a few miles to its northern terminus with SR 158.