State Route 333 (SR 333) is a south–north route located entirely in Brooks County in the extreme southern part of the U.S. state of Georgia.

SR 333 begins at the Florida state line southeast of Quitman, where the roadway continues as Florida State Road 53. The route runs northwest to Quitman, where it intersects US 221/SR 76 in the southern part of the city. The three routes form a concurrency into downtown, where they intersect US 84/SR 38. At this point, US 221 departs to the east, and SR 76/SR 333 continue to the northern part of the city, where SR 76 departs to the east. Then, SR 333 continues north, intersecting SR 122 just south of its northern terminus, SR 133 southeast of Berlin.

The entire route is in Brooks County.