State Route 116 (SR 116) is a state highway that runs west-to-east through portions of Harris and Talbot counties in west-central Georgia. The route runs from its western terminus at I-185/SR 411 west of Hamilton to its eastern terminus at SR 41 northwest of Woodland.

In Shiloh, the route turns sharply south and is co-signed with US 27 and SR 85 for just under 2 miles (3.2 km), before heading back east as SR 116.