Highway 352 is an east–west highway in western Arkansas. Its western terminus is Highway 23 approximately 5 miles (8.0 km) north of Ozark. Its eastern terminus is U.S. Highway 64 in Clarksville. The route is a 2-lane rural highway its complete length which parallels and at times meets Interstate 40.

AR 352 begins at AR 23 and runs east to meet AR 219 in Mountain Grove. It continues east, meeting AR 164 in Hunt before angling south to cross over I-40. The route runs south of I-40 until it again crosses over the road, after which it terminates at US 64 in Clarksville.