State Route 159 or SR-159 is a 29.626-mile (47.678 km) state highway that serves as a north-south connection between Gordo and Fayette through Fayette and Pickens Counties. SR-159 intersects US-82 at its southern terminus and SR-171 at its northern terminus.

State Route 159 begins at its intersection with US-82 in the central business district of Gordo. From this point, SR-159 follows a meandering northerly course through norther Pickens County and southern Fayette County in route to its northern terminus at SR-171 in Fayette.