State Route 153 or SR-153 is a 8.994-mile (14.474 km) state highway that serves as a north-south connection in western Geneva County. SR-153 intersects begins at the Florida state line and terminates at SR-52 west of Samson.

State Route 153 begins at the Florida where its is a continuation of Florida State Road 83. From this point the route generally travels in a northerly direction through its northern terminus at SR-52 west of Samson.

The entire route is in Geneva County.