State Route 141 (SR-141) is a 14.430-mile (23.223 km) state highway in southeastern Alabama. The highway runs from SR-189 southeast of Elba north to U.S. Route 331 (US 331) and SR-9 south of Brantley.

SR-141 begins at a junction with SR-189 in rural Coffee County, southeast of Elba. From here, the highway heads north-northwest through farmland until it intersects US 84; the two routes briefly overlap. SR-141 continues north past this intersection and meets SR-166 at its western terminus in Danleys Crossroads. Past this junction, SR-141 heads north through a rural area before turning northwest and entering Crenshaw County. The highway runs northwest from here to its terminus at the concurrent US 331 and SR 9 south of Brantley.