State Route 103 is a 17-mile (27 km) long route in southeastern Alabama. The route begins at the Florida-Alabama state line and is a continuation of Former Florida State Road 171. The northern terminus of the route is at its junction with State Route 123 at Wicksburg, an unincorporated community north of the Geneva-Dale County line.

State Route 103 travels primarily through eastern Geneva County. It is one of numerous routes that enter Alabama from the Florida Panhandle. Upon entering Alabama, the route leads northward, passing primarily through rural areas of the county along a two-lane roadway. At the approximate halfway point of the route, it passes through Slocomb, the only incorporated community along its route.