Alaska Route 2 is a state highway in the central and east-central portions of the U.S. state of Alaska. It runs from Manley Hot Springs to the International Border, passing through Fairbanks and Delta Junction. Alaska Route 2 includes the entire length of the Alaska Highway in the state, the remainder of the highway being in the Yukon Territory, Canada.

Route 2 begins at a dead end near the Tanana River at Manley Hot Springs, where the Elliott Highway begins. Until the junction with the Dalton Highway (Alaska Route 11) at Livengood, Route 2 is a minor road used only for local access; beyond Livengood it carries traffic to and from the Dalton Highway. At the junction with Alaska Route 6 (Steese Highway) at Fox, the Elliott Highway ends and Route 2 follows the Steese Highway south into Fairbanks. The Steese Highway becomes the Richardson Highway at Airport Way, the former route of the Parks Highway (Alaska Route 3). The Parks Highway junction is now about a mile south along the Richardson Highway, which then leaves Fairbanks to the southeast. In Delta Junction, at the northwest end of the Alaska Highway, Route 2 leaves the Richardson Highway for the Alaska Highway, while the Richardson Highway continues south as Alaska Route 4. After passing the ends of the Tok Cut-Off Highway (Alaska Route 1) at Tok and the Taylor Highway (Alaska Route 5) just beyond, Route 2 becomes Yukon Highway 1 at the Canadian border.

Route 2 is an unsigned part of the Interstate Highway System east of Fairbanks. The entire length of Interstate A-2 follows Route 2 from the George Parks Highway (Interstate A-4) junction in Fairbanks to Tok, east of which Route 2 carries Interstate A-1 off the Tok Cut-Off Highway to the national border. Only a short piece of the Richardson Highway in Fairbanks is built to freeway standards.

The Alaska Highway portion of Route 2 was once proposed to be part of the U.S. Highway System, to be signed as part of U.S. Route 97.

A 500 mile road reaching Nome in western Alaska has been proposed at various times. Such a road had been suggested as early as 1957. From 2009 onward, there has been a more intense political debate. A detailed cost investigation was funded by the state government, which gave an estimated cost of $2.3 to $2.7 billion, or approximately $5 million per mile. This price tag is higher than previously assumed. This has caused hesitation about the project. The debate is continuing in 2011.